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Significance: The oxazole diterpenoids ileabethoxazole, pseudopteroxazole and seco-pseudopteroxazole, isolated from Pseudopterogorgia elisabethae, possess potent inhibitory activity against Mycobacterium tuberculosis. Structurally, these natural products are characterized by a hexasubstituted benzene connected to an oxazole. Li and co-workers achieved the total syntheses of these targets relying on a palladium cascade reaction followed by a 6π-electrocyclization. Comment: Alkyne A, available in six steps from (+)-isopulegol, undergoes a palladium-catalyzed cascade reaction to give C in 55% yield. Upon heating in the presence of air, the desired 6π-electrocyclization occurred, providing key intermediate D. Later, alkyne F was obtained, which underwent a radical cyclization ultimately leading to (+)-ileabethoxazole. Furthermore, both (+)-pseudopteroxazole and (+)-seco-pseudopteroxazole could be accessed from D. O Si(i-Pr)2 H N O TIPS

Synthesis of Ileabethoxazole, Pseudo-pteroxazole, and seco-Pseudopteroxazole