English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Significance: Aliphatic amines are present in many pharmaceutical agents and they are often essential for activity. The potential of stereoisomers to have contrasting biological effects means that asymmetric approaches to construct aminecontaining remote stereocenters has been a challenge. Buchwald and co-workers report an asymmetric copper-catalyzed hydroamination reaction that generates γand δ-chiral aliphatic amines. Comment: The copper-catalyzed hydroamination reaction produced the desired aliphatic amines in good to excellent yields and with excellent enantioand diastereoselectivities. The proposed mechanism starts with the formation of an alkylcopper species and subsequent β-alkoxide elimination to form the enantioenriched alkene. The hydrosilane reagent regenerates the CuH catalyst, which undergoes the anti-Markovnikov hydrocupration to form the terminal alkylcopper species. Finally, interception with the hydroxylamine generates the product, and the hydrosilane reagent regenerates the CuH catalyst. O

Aliphatic Amines Formed by Asymmetric Copper-Catalyzed Hydroamination