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We carried out an adapted Kausch–Whipple operation with gastro-pancreatic anastomosis in a 65-year-old male patient with duodenal adenocarcinoma (pT3, pN0, M0, R0). On postoperative day 2 we observed substantial discharge of air and biliary fluid from the perianastomotic drain. Initial endoscopy showed a semicircular dehiscence of the pancreaticogastric anastomosis (●" Fig.1). The postpyloric anastomosis was intact. There was no general abdominal guarding in the spontaneously breathing and hemodynamically stable patient. An intraluminal vacuum drainage system (●" Fig.2) constructed from a long openpore polyurethane foam (length 12cm and diameter 2cm) and a gastric tube (B.Braun Endo-SPONGE, Melsungen, Germany; Ventrol, 14Ch×120cm, Covidien, Dublin, Ireland) was placed over the anastomosis. We have described the procedure in previous publications [1]. Applying a continuous negative pressure of 125mmHg (V.A.C. Freedom, Kinetic Concepts, Inc. San Antonio, Texas, USA) resulted in the intended collapse of the stomach around the vacuum drainage system and complete evacuation of all digestive fluids (●" Fig.3). After placement of drainage system, biliary discharge from postoperative drain decreased as did the levels of inflammatory parameters. The patient was on parenteral nutrition but was allowed to drink water. A follow-up endoscopy 4 days after the procedure revealed the anastomotic dehiscence had reduced in size and no discharge of air into the perianastomotic drain. The stomach had completely collapsed around the intraluminal vacuum drainage. The mucosa showed the typical erosion pattern (●" Fig.4) and swift evacuation of the flushing fluid was indicative of normal function of the vacuum drainage, which was thus left in place. On day 8 there were no endoscopic signs of anastomotic leakage and vacuum therapy was terminated. Additional conventional contrast imaging did not show signs of leakage and the patient was switched to full liquid oral nutrition. Follow-up endoscopy 3 and 7 days after therapy (●" Fig.5) showed no recurrence of the anastomotic dehiscence. The patient was put on full oral nutrition and the perianastomotic drain was removed. Another follow-up endoscopy of the asymptomatic patient 75 days after therapy revealed normal postoperative condition.

Pancreatico-gastric anastomotic insufficiency successfully treated with endoscopic vacuum therapy