English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The title diynediol was synthesized in enantiopure (>98.4% ee) forms, with the cross coupling of phenylacetylene with either (R)- or (S)-5-benzyloxypent-1-yn-4-ol catalyzed by nickel(II) chloride-copper(I) iodide as the key step. Comparison of the spectroscopic data (especially the optical rotations) for the synthetic and natural samples revealed that the natural diynediol is of S-configuration. The unexpected formation of a pyranone ring at the alkyne terminal when cleaving a benzyl protecting group with acetic anhydride and trimethylsilyl triflate is also detailed; this approach illustrates a novel and mild entry to related pyranones.

Synthesis and Absolute Configuration of the 7-Phenylhepta-4,6-diyne-1,2-diol Isolated from Bidens pilosa