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of diabetes mellitus underwent esophagogastroduodenoscopy (EGD) as part of a medical check-up. He had no symptoms. EGD revealed a semipedunculated polyp, 50mm long and 20mm in diameter, in the thoracic esophagus (●" Fig. 1a). The polyp was covered by normal mucosa with mildly dilated vessels (●" Fig. 1b,c). Endoscopic ultrasound (EUS) showed multilocular hypoechoic areas within the second layer (●" Fig. 2) and an intact fourth layer in the stalk of the polyp. Double-contrast esophagogram also showed a semipedunculated polyp hanging down from the thoracic esophagus (●" Fig. 3). Although the esophageal polyp was thought likely to be a submucosal cyst of the esophagus, the patient requested treatment of the polyp before symptoms, such as discomfort in the esophagus or dysphagia, developed. The patient understood the risks of endoscopic treatment and provided written informed consent. Endoscopic treatment was performed without any complications. The size of the resected specimen was 53 × 23 × 15mm (●" Fig. 4). Histopathological evaluation of the resected specimendemonstratedmultiple cysts lined internally by cuboidal epithelium in the submucosa and a small chondrosis in the stroma, and that the mucosa covering the polyp consisted of normal squamous epithelium (●" Fig. 5). The polyp was diagnosed as a retention cyst with chondromatous metaplasia in the esophagus. Although retention cysts are the most common benign lesion in the pharynx [1], they are uncommon in the esophagus [2–4]. An esophageal squamous cell carcinoma coexisting with a submucosal retention cyst has been reported [4]. To our knowledge, this is the first report of a large esophageal retention cyst with chondromatous metaplasia that was treated endoscopically. As this cyst did not consist of ciliated epithelium, it is assumed that it was not of bronchial origin. We were not able to determine the cause of the chondrosis.

Large retention cyst with chondromatous metaplasia in the esophagus