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Early human tolerance following total body irradiation (TBI) according to the dose received is still poorly known. Thirteen selected patients were prospecti­ vely evaluated for clinical side effects during the first 10 hours following a 2 Gy TBI prior to bone marrow transplantation. All of them but one were treated for haematological malignancies and were in clinical remission at the date of TBI. There were 10 males and 3 females, with a median age of 43 y (range 16-61) and a good performance status (WHO 0-1). They received granisetron (3 mg) injec­ ted intravenously 1 h before the time of TBI in order to prevent nausea and vomiting. The main symptoms consisted in drowsiness (69 %), headache (62 %), xerostomia (62 %), nausea and vomiting (46 %), anorexia (38 %), parotid gland pain (23 %) and abdominal pain (8 %). Their intensity was always moderate, except for 2 patients who experimented severe vomiting. The incidence rate and the time-course of the symptoms of the prodromal phase may proved to be helpful for early clinical evaluation and triage of victims of an accidental irra­ diation. In particular, absence of fever at the 6 th h after TBI supports the assumption of an estimated exposure dose below 2 Gy.

Etude prospective de la symptomatologie clinique précoce après irradiation corporelle totale thérapeutique de 2 Gy