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Most  Schistosoma mansoni  experimental infections are developed in several inbred strains of  Mus musculus  as definitive host. In contrast,  Mus spretus  is unexplored in  Schistosoma  infection studies.  Mus spretus  provides a high variation of immunological phenotypes being an invaluable tool for genetic studies and gene mapping. The aim of this study is to characterize hematological and immunological responses against  Schistosoma mansoni  infection in  Mus spretus  (SPRET/EiJ strain)  vs. Mus musculus  (CD1 strain) mice. Nine weeks after cercarial exposure, animals were perfused and the parasite burden was assessed. The parasitological data suggests that SPRET/EiJ mice tolerate higher parasite loads compared to CD1 strain. In addition, hematological parameters measured in  Mus spretus  group showed a significant increase in granulocytes population in early stages of infection compared to the CD1 cohort. Meanwhile, CD1 presented higher levels of lymphocytes and IgG1 in the late stages of  S. mansoni  experimental infection.

Schistosoma mansoniexperimental infection inMus spretus(SPRET/EiJ strain) mice