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1053 m/s n° 12, vol. 32, décembre 2016 DOI : 10.1051/medsci/20163212003 4. Jakupovic I, Grandage VL, Linch DC, et al. Lack of effect of the human GM-CSF analog E21R on the survival of primary human acute myeloid leukemia cells. Blood 2004 ; 103 : 3230-2. 5. Mathew M, Zaineb KC, Verma RS. GM-CSF-DFF40: a novel humanized immunotoxin induces apoptosis in acute myeloid leukemia cells. Apoptosis 2013 ; 18 : 882-95. 6. Hibbs ML, Harder KW. The duplicitous nature of the Lyn tyrosine kinase in growth factor signaling. Growth Factors 2006 ; 24 : 137-49. 7. Scapini P, Pereira S, Zhang H, et al. Multiple roles of Lyn kinase in myeloid cell signaling and function. Immunol Rev 2009 ; 228 : 23-40. 8. Wei S, Liu JH, Epling-Burnette PK, et al. Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor. J Immunol 1996 ; 157 : 5155-62. 9. Simons K, Toomre D. Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 2000 ; 1 : 31-9. 10. Saint-Paul L, Nguyen CH, Buffière A, et al. CD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid rafts. Oncotarget 2016 ; doi: 10.18632/oncotarget.11622. PyQ apparaît donc être une molécule d’intérêt avec un potentiel pharmacologique pour le traitement des LAM. ‡ CD45 phosphatase, a relevant target for the treatment of acute myeloid leukemia

L’antisynapse : présynapse et garde-fou de l’activation lymphocytaire ?