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m/s n° 12, vol. 31, decembre 2015 DOI : 10.1051/medsci/20153112006 7. Bansil R and Turner BS. Mucin structure, aggregation, physiological functions and biomedical applications. Curr Opin Colloid Interface 2006 ; 11 : 164-70. 8. Gouyer V, Dubuquoy L, Robbe-Masselot C, et al. Delivery of a mucin domain enriched in cysteine residues strengthens the intestinal mucous barrier. Sci Rep 2015 ; 5 : 9577. 9. Desseyn JL. Mucin CYS domains are ancient and highly conserved modules that evolved in concert. Mol Phylogenet Evol 2009 ; 52 : 284-92. 10. Borges S, Silva J, Teixeira P. The role of lactobacilli and probiotics in maintaining vaginal health. Arch Gynecol Obstet 2014 ; 289 : 479-89. 11. Brunelli R, Papi M, Arcovito G, et al. Globular structure of human ovulatory cervical mucus. FASEB J 2007 ; 21 : 3872-6. 12. Perez-Vilar J and Boucher RC. Reevaluating gelforming mucins’ roles in cystic fibrosis lung disease. Free Radic Biol Med 2004 ; 37 : 1564-77. 13. Backstrom M, Ambort D, Thomsson E, et al. Increased understanding of the biochemistry and biosynthesis of MUC2 and other gel-forming mucins through the recombinant expression of their protein domains. Mol Biotechnol 2013 ; 54 : 250-6. LIENS D’INTERET Les auteurs declarent n’avoir aucun lien d’interet concernant les donnees publiees dans cet article.

Efficacité et sécurité du traitement par thérapie génique des patients atteints du syndrome de Wiskott-Aldrich