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253 m/s n° 3, vol. 31, mars 2015 DOI : 10.1051/medsci/20153103009 6. Marthiens V, Rujano MA, Pennetier C, et al. Centrosome amplification causes microcephaly. Nat Cell Biol 2013 ; 15 : 731-40. 7. Lingle WL, Barrett SL, Negron VC, et al. Centrosome amplification drives chromosomal instability in breast tumor development. Proc Natl Acad Sci USA 2002 ; 99 : 1978-83. 8. Ganem NJ, Godinho SA, Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature 2009 ; 460 : 278-82. 9. Godinho SA, Picone R, Burute M, et al. Oncogenelike induction of cellular invasion from centrosome amplification. Nature 2014 ; 510 : 167-71. 10. Marcet B, Chevalier B, Luxardi G. Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta / Notch pathway. Nat Cell Biol 2011 ; 13 : 694-701. 11. Wang L, Fu C, Fan H, et al. miR-34b regulates multiciliogenesis during organ formation in zebrafish. Development 2013 ; 140 : 2755-64. 12. Ma L, Quigley I, Omran H, Kintner C. Multicilin drives centriole biogenesis via E2f proteins. Genes Dev 2014 ; 28 : 1461-71. LIENS D’INTERET Les auteurs declarent n’avoir aucun lien d’interet concernant les donnees publiees dans cet article.

Un nouvel outil pour le traitement de la myopathie de Duchenne : les tricyclo-ADN