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Trabecular bone microarchitecture changes in relation to mechanical stress, effects of age, osteoporosis and anti-osteoporotic drugs. In vivo, these anomalies can be evaluated using textural parameters on high resolution radiographs and images of DXA. It is possible to extract morphological and topological parameters: apparent on MRI images and 3D with a dedicated device called High resolution peripheral quantitative computed tomography (HR-pQCT) with a resolution close to the size of the trabeculae. In vitro, it is possible to obtain on bone samples a 2D analysis by histomorphometry and a 3D analysis from 10 µm images obtained by synchrotron radiation or conventional micro-CT.

Méthodes d’évaluation de la microarchitecture de l’os trabéculaire humain