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1. McDermott DF. Immunotherapy of metastatic renal cell carcinoma. Cancer 2009 ; 115 (suppl 10) : 2298-305. 2. Stagg J, Wu JH, Bougamin N, et al. Granulocytemacrophage colony-stimulating factor and interleukin-2 fusion of cDNA for cancer gene immunotherapy. Cancer Res 2004 ; 64 : 8795-99. 3. Rafei M, Wu JH, Annabi B, et al. A GMCSF and IL15 Fusokine Leads to paradoxical immunosuppression in vivo via asymetrical JAK/STAT signaling through the IL15 receptor complex. Blood 2007 ; 109 : 2234-42. 4. Hartung HP, Bar-Or A, Zoukos Y. What do we know about the mechanism of action of disease-modifying treatments in MS? J Neurol 2004 ; 251 (suppl 5) : v12-29. 5. Stern JN, Keskin DB, Zhang H, et al. Amino acid copolymerspecific IL-10-secreting regulatory T-cells that ameliorate autoimmune diseases in mice. Proc Natl Acad Sci USA 2008 ; 105 : 5172-6. 6. Neta R, Salvin SB. Specific suppression of delayed hypersensitivity: the possible presence of a suppressor B cell in the regulation of delayed hypersensitivity. J Immunol 1974 ; 113 : 1716-25. 7. Fillatreau S, Sweenie CH, McGeachy MJ, et al. B cells regulate autoimmunity by provision of IL-10. Nat Immunol 2002 ; 3 : 944-50. 8. Bouaziz JD, Yanaba K, Tedder TF. Regulatory B cells as inhibitors of immune responses and inflammation. Immunol Rev 2008 ; 224 : 201-14. 9. Rafei M, Hsieh J, Zehntner S, et al. A granulocytemacrophage colony-stimulating factor and interleukin-15 fusokine induces a regulatory B cell population with immune suppressive properties. Nat Med 2009 ; 15 : 1038-45. 10. Rafei M, Campeau PM, Wu JH, et al. Selective inhibition of CCR2 expressing lymphomyeloid cells in experimental autoimmune encephalomyelitis by a GM-CSF-MCP1 fusokine. J Immunol 2009 ; 182 : 2620-7. 11. Papeix C, Lubetzki C. Anticorps monoclonaux dans la sclerose en plaques. Med Sci 2009 ; 25 : 1113-5.

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