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M/S n° 6-7, vol. 25, juin-juillet 2009 3. Dokun AO, Kim S, Smith HR, et al. Specific and nonspecific NK cell activation during virus infection. Nat Immunol 2001 ; 2 : 951-6. 4. Robbins SH, Tessmer MS, Mikayama T, Brossay L. Expansion and contraction of the NK cell compartment in response to murine cytomegalovirus infection. J Immunol 2004 ; 173 : 259-66. 5. Bekiaris V, Timoshenko O, Hou TZ, et al. Ly49H+ NK cells migrate to and protect splenic white pulp stroma from murine cytomegalovirus infection. J Immunol 2008 ; 180 : 6768-76. 6. O’Leary JG, Goodarzi M, Drayton DL, von Andrian UH. T celland B cell-independent adaptive immunity mediated by natural killer cells. Nat Immunol 2006 ; 7 : 507-16. 7. Cooper MA, Elliott JM, Keyel PA, et al. Cytokineinduced memory-like natural killer cells. Proc Natl Acad Sci USA 2009 ; 106 : 1915-9. 8. Arstila TP, Casrouge A, Baron V, et al. Diversity of human alpha beta T cell receptors. Science 2000 ; 288 : 1135. 9. Badovinac VP, Haring JS, Harty JT. Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8+ T cell response to infection. Immunity 2007 ; 26 : 827-41. 10. Kaech SM, Tan JT, Wherry EJ, et al. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol 2003 ; 4 : 1191-8. 11. Almeida JR, Price DA, Papagno L, et al. Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover. J Exp Med 2007 ; 204 : 2473-85.

La clé vers de nouveaux inhibiteurs de iNOS