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This paper reports on a new analysis of archival ALMA $870\,\mu$m dustcontinuum observations. Along with the previously observed bright inner ring($r \sim 20-40\,$au), two addition substructures are evident in the newcontinuum image: a wide dust gap, $r \sim 40-150\,$au, and a faint outer ringranging from $r \sim 150\,$au to $r \sim 250\,$au and whose presence wasformerly postulated in low-angular-resolution ALMA cycle 0 observations butnever before observed. Notably, the dust emission of the outer ring is nothomogeneous, and it shows two prominent azimuthal asymmetries that resemble aneccentric ring with eccentricity $e = 0.07 $. The characteristic double-ringdust structure of HD 100546 is likely produced by the interaction of the diskwith multiple giant protoplanets. This paper includes newsmoothed-particle-hydrodynamic simulations with two giant protoplanets, oneinside of the inner dust cavity and one in the dust gap. The simulationsqualitatively reproduce the observations, and the final masses and orbitaldistances of the two planets in the simulations are 3.1 $M_{J}$ at 15 au and8.5 $M_{J}$ at 110 au, respectively. The massive outer protoplanetsubstantially perturbs the disk surface density distribution and gas dynamics,producing multiple spiral arms both inward and outward of its orbit. This canexplain the observed perturbed gas dynamics inward of 100 au as revealed byALMA observations of CO.  Finally, the reduced dust surface density in the $\sim 40-150\,$au dust gapcan nicely clarify the origin of the previously detected H$_2$O gas and iceemission.

ALMA 870 $\mu$m continuum observations of HD 100546. Evidence of a giant planet on a wide orbit