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This research aims to investigate the expression profile of circRNA in osteosarcoma and to identify the underlying pathogenesis core genes of osteosarcoma.Methods : Illumina HiSeq was used to screen differentially expressed circRNAs between the tumour tissues and paracancerous tissues of three osteosarcoma patients. Bioinformatics analysis was used to analyse their potential functions. Five differentially expressed circRNAs were selected to detect the relative expression level in tumour and paracancerous tissues of ten osteosarcoma patients by real-time PCR. The databases such as DisGeNET and miRWalk were used to collect related genes or miRNAs.

Differential expression and bioinformatics analysis of circRNA in osteosarcoma