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Trisubstituted imidazoles are synthesized efficiently from the readily available 1,2-diketones and aldehydes using hexamethyldisilazane as a new and stable nitrogen source under TMSOTf-catalysis system, microwave heating and solvent-free conditions.

rsc advances

TMSOTf-catalyzed synthesis of trisubstituted imidazoles using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions