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SirSince the anti-oestrogen tamoxifen has partial agonist, oestrogen-like effects on the uterus, progestins could theoretically be used –as in hormone replacement therapy (HRT) – to protect the uterusfrom excessive stimulation. There are, however, very few data onthe effects of this association: therefore, we read with interest anarticle by Powles et al (

Progestins and the endometrium in patients receiving tamoxifen