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In this study, the toxic effects of aflatoxin B 2  (AFB 2 ) on Swiss albino mice and the protective effects of resveratrol were investigated. Physiological (body weight, liver and kidney weight), biochemical (aspartate aminotransferase-AST, alanine transaminase-ALT, blood urea nitrogen-BUN, creatinine, malondialdehyde-MDA and glutathione-GSH) and cytogenetic parameters (micronucleus-MN in buccal epithelium, erythrocyte and leukocyte cells and chromosomal aberrations-CAs) were used to determine the toxic effects. Additionally, scavenging effects of resveratrol against superoxide, hydrogen peroxide (H 2 O 2 ) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals were also investigated. In experimental period, mice were divided into six groups and the groups were treated with tap water, 10 mg/kg b.w resveratrol, 20 mg/kg b.w resveratrol, 20 µg/kg b.w. AFB 2 , 10 mg/kg b.w resveratrol + 20 µg/kg b.w AFB 2 , 20 mg/kg b.w resveratrol + 20 µg/kg b.w AFB 2 , respectively. As a result, the scavenging effects of resveratrol increased with increasing dose and the superoxide, H 2 O 2  and DPPH radical scavenging activity of resveratrol were 74.9%, 79.1% and 49.2%, respectively. AFB 2  administration caused a significant decrease in physiological parameters, and these decreases regressed in AFB 2  + resveratrol treated groups. Serum ALT and AST activities, BUN and creatinine levels were higher in the AFB 2  treated group compared to the control group and serious abnormalities were found in MDA and GSH levels in the kidney and liver. In the group treated with AFB 2  + 20 mg/kg resveratrol, ALT, AST, BUN and creatinine levels decreased significantly and GSH levels increased compared to only-AFB 2  treated group. AFB 2  triggered MN formation in buccal epithelium, erythrocyte and leukocyte cells and CAs in bone marrow cells. The application of 20 mg/kg resveratrol together with AFB 2  was decreased the MN and CAs frequency. Resveratrol exhibited a recovery effect in the range of 40.9–80.5% against AFB 2  toxicity in all tested parameters. In this study, it was determined that AFB 2  caused serious changes in selected physiological, biochemical and cytogenetic parameters while resveratrol displayed a protective role against these toxic effects.

Combined toxic effects of aflatoxin B2 and the protective role of resveratrol in Swiss albino mice