English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The major lysosomal proteases, Cathepsin B (CTSB), Cathepsin D (CTSD) and Cathepsin L (CTSL), are implicated in autophagic activity. To investigate the role of each cathepsin in the exocrine pancreas, we generated mice in which the pancreas was specifically deficient in  Ctsb, Ctsd  and  Ctsl . Each of these gene knockout (KO) and  Ctsb;Ctsl  and  Ctsd;Ctsl  double-knockout (DKO) mice were almost normal. However, we found cytoplasmic degeneration in the pancreatic acinar cells of  Ctsb;Ctsd  DKO mice, similar to autophagy related 5 ( Atg5 ) KO mice. LC3 and p62 (autophagy markers) showed remarkable accumulation and the numbers of autophagosomes and autolysosomes were increased in the pancreatic acinar cells of  Ctsb;Ctsd  DKO mice. Moreover, these  Ctsb;Ctsd  DKO mice also developed chronic pancreatitis (CP). Thus, we conclude that both  Ctsb  and  Ctsd  deficiency caused impaired autophagy in the pancreatic acinar cells, and induced CP in mice.

Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis