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We investigated morphological changes of retinal arteries to determine their association with the blood flow and systemic variables in type 2 diabetes patients. The patients included 47 non-diabetic retinopathy eyes, 36 mild or moderate nonproliferative diabetic retinopathy (M-NPDR) eyes, 22 severe NPDR (S-NPDR) eyes, 32 PDR eyes, and 24 normal eyes as controls. The mean wall to lumen ratio (WLR) measured by adaptive optics camera was significantly higher in the PDR groups than in all of the other groups (all  P  < 0.001). However, the external diameter of the retinal vessels was not significantly different among the groups. The mean blur rate (MBR)-vessel determined by laser speckle flowgraphy was significantly lower in the PDR group than in the other groups ( P  < 0.001). The WLR was correlated with MBR-vessel ( r  = − 0.337,  P  < 0.001), duration of disease ( r  = 0.191,  P  = 0.042), stage of DM ( r  = 0.643,  P  < 0.001), systolic blood pressure ( r  = 0.166,  P  < 0.037), and presence of systemic hypertension ( r  = 0.443,  P  < 0.001). Multiple regression analysis demonstrated that MBR-vessel (β = − 0.389,  P  < 0.001), presence of systemic hypertension (β = 0.334,  P  = 0.001), and LDL (β = 0.199,  P  = 0.045) were independent factors significantly associated with the WLR. The increased retinal vessel wall thickness led to a narrowing of lumen diameter and a decrease in the blood flow in the PDR group.

Association of changes of retinal vessels diameter with ocular blood flow in eyes with diabetic retinopathy