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High levels of persistent organic pollutants (POPs) and heavy metals are found in Arctic populations. POP and heavy metals are linked to impaired cognitive development. This study examined associations between prenatal POP and metals exposure and problematic child behavior using the Strength and Difficulties Questionnaire (SDQ). POPs and metals were measured in 102 pregnant Greenlandic women. During follow-up at 3–5 years, parents answered an assisted questionnaire including children’s SDQ scores. Associations were analyzed using linear and logistic regression analyses and adjusted for maternal plasma cotinine, educational level and age at delivery. In the adjusted analyses, the medium tertile of hexachlorobenzene (β = 3.06,  p  = 0.010), β-hexachlorocyclohexane (β = 3.58,  p  = 0.004) and trans-nonachlor (β = 2.06,  p  = 0.082) were positively associated with SDQ scores. The continuous cis-nonachlor (OR = 1.09,  p  = 0.079), dichloro-diphenyl-dichloroethylene (OR = 1.01,  p  = 0.077), trans-nonachlor (OR = 1.01,  p  = 0.091), and sum Organochlorine-Pesticides (OR = 1.00,  p  = 0.094) were positively associated with abnormal SDQ score and the continuous mirex (OR = 1.28,  p  = 0.096), oxychlordane (OR = 1.04,  p  = 0.066), and trans-nonachlor (OR = 1.02,  p  = 0.071) with abnormal hyperactivity score. We found no consistent evidence of associations between polychlorinated biphenyls, perfluoroalkylated substances and heavy metals and problematic behavior. Prenatal organochlorine pesticide exposure associated significantly with problematic behavior in 3–5 year old children.

Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3–5 years of age: a Greenlandic cohort study