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A new series of 5-arylhydrazonothiazole derivatives  5a–d  has been synthesized, elucidated, and evaluated for their antidermatophytic activity. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of the newly synthesized products were investigated against 18 dermatophyte fungal isolates related to  Epidermophyton floccosum ,  Microsporum canis , and  Trichophyton rubrum . The morphological alterations induced by the synthesized derivatives singly or conjugated with the monoclonal antibody were examined on spores of  T. rubrum  using a scanning electron microscope. The efficacy of synthesized derivative  5a  applied at its respective MFC alone or conjugated with anti-dermatophyte monoclonal antibody 0014 in skin infection treatment of guinea pigs due to inoculation with one of the examined dermatophytes, in comparison with fluconazole as standard reference drug was evaluated. In an in vivo experiment, the efficiency of  5a  derivative conjugated with the antibody induced 100% healing after 45 days in the case of  T. rubrum  and  M. canis -infected guinea pigs.

Antidermatophytic activity of some newly synthesized arylhydrazonothiazoles conjugated with monoclonal antibody