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Agaricus bisporus , the most cultivated edible mushroom worldwide, is represented mainly by the subspecies var.  bisporus  and var.  burnettii . var.  bisporus  has a secondarily homothallic life cycle with recombination restricted to chromosome ends, while var.  burnettii  is heterothallic with recombination seemingly equally distributed over the chromosomes. To better understand the relationship between genomic make-up and different lifestyles, we have de novo sequenced a  burnettii  homokaryon and synchronised gene annotations with updated versions of the published genomes of var.  bisporus . The genomes were assembled into telomere-to-telomere chromosomes and a consistent set of gene predictions was generated. The genomes of both subspecies were largely co-linear, and especially the chromosome ends differed in gene model content between the two subspecies. A single large cluster of repeats was found on each chromosome at the same respective position in all strains, harbouring nearly 50% of all repeats and likely representing centromeres. Repeats were all heavily methylated. Finally, a mapping population of var.  burnettii  confirmed an even distribution of crossovers in meiosis, contrasting the recombination landscape of var.  bisporus . The new findings using the exceptionally complete and well annotated genomes of this basidiomycete demonstrate the importance for unravelling genetic components underlying the different life cycles.

scientific reports

Telomere-to-telomere assembled and centromere annotated genomes of the two main subspecies of the button mushroom Agaricus bisporus reveal especially polymorphic chromosome ends