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Symptoms of  Staphylococcus lugdunensis  infection are often similar to those of  Staphylococcus aureus  infection, including skin and soft-tissue lesions, bacteremia and infective endocarditis. Despite the severity of these infections,  S. lugdunensis  is regarded as a less important pathogen than drug-resistant  S. aureus . To investigate its ability to cause infectious diseases, a methicillin-resistant  S. lugdunensis  (MRSL) strain JICS135 was isolated from a patient with bacteremia and subjected to whole genome sequencing. Similar to most strains of methicillin-resistant  S. aureus  (MRSA), this MRSL strain possessed the staphylococcal cassette chromosome  mec  (SCC mec ) located close to the origin of replication. However, the SCC mec  in this MRSL strain, with three  ccr  complexes, was structurally unique and currently untypable. Moreover, the SCC mec  of this MRSL strain was found to carry two genes encoding microbial surface components recognizing adhesive matrix molecules (MSCRAMM)-like proteins accompanied by glycosyl transferases, one of which may have been derived from  S. aureus  and the other from  S. epidermidis , indicating that this MRSL evolved to carry virulence factors from other staphylococci. The emergence of this strain, the first MRSL strain whose genome has been sequenced completely, may be of public concern.

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Complete genome sequence of a methicillin-resistant Staphylococcus lugdunensis strain and characteristics of its staphylococcal cassette chromosome mec