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Pseudomonas aeruginosa  is an opportunistic human pathogen causing infections in a variety of plant and animal hosts. The gene  mcpB , part of the chemosensory gene cluster II, encodes a soluble chemoreceptor whose function remains unknown. Previous studies show that the  cheB2  gene, also located in the chemosensory cluster II, is involved in a specific response during infection and it is required for full pathogenicity of  P .  aeruginosa . To determine whether the McpB (or Aer2) chemoreceptor is involved in virulence processes, we generated a  mcpB  mutant and tested its phenotype using a virulence-measuring system. This system was developed by our group and is based on different bioassays using organisms living at different soil trophic levels, including microbial, nematode, arthropod, annelid, and plant model systems. The deletion of  mcpB  resulted in an attenuation of bacterial virulence in different infection models, and wild-type virulence was restored following genetic complementation of the mutant strain. Our study indicates that the McpB chemoreceptor is linked to virulence processes and may constitute the basis for the development of alternative strategies against this pathogen.

The involvement of McpB chemoreceptor from Pseudomonas aeruginosa PAO1 in virulence