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Gsdf  is a key gene for testicular differentiation in teleost. However, little is known about the function of  Gsdf  in Chinese tongue sole ( Cynoglossus semilaevis ). In this study, we obtained the full-length  Gsdf  gene ( CS - Gsdf ), and functional characterization revealed its potential participation during germ cell differentiation in testes.  CS - Gsdf  transcription was predominantly detected in gonads, while the levels in testes were significantly higher than those in ovaries. During the different developmental stages in male gonads, the mRNA level was significantly upregulated at 86 dph, and a peak appeared at 120 dph; then, the level decreased at 1 and 2 yph.  In situ  hybridization revealed that  CS-Gsdf  mRNA was mainly localized in the Sertoli cells, spermatogonia, and spermatids in mature testes. After  CS-Gsdf  knockdown in the male testes cell line by RNA interference, a series of sex-related genes was influenced, including several sex differentiation genes,  CS-Wnt4a ,  CS-Cyp19a1a  and  CS-Star . Based on these data, we speculated that  CS-Gsdf  may play a positive role in germ differentiation and proliferation via influencing genes related to sex differentiation.

The autosomal Gsdf gene plays a role in male gonad development in Chinese tongue sole (Cynoglossus semilaevis)