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Growing evidence has shown that gut microbiome is a key factor involved in liver health. Therefore, gut microbiota modulation with probiotic bacteria, such as  Saccharomyces boulardii , constitutes a promising therapy for hepatosis. In this study, we aimed to investigate the protective effects of  S. boulardii  on D-Galactosamine-induced liver injury in mice. Liver function test and histopathological analysis both suggested that the liver injury can be effectively attenuated by  S. boulardii  administration. In the meantime,  S. boulardii  induced dramatic changes in the gut microbial composition. At the phylum level, we found that  S. boulardii  significantly increased in the relative abundance of  Bacteroidetes , and decreased the relative abundance of  Firmicutes  and  Proteobacteria , which may explain the hepatic protective effects of  S. boulardii . Taken together, our results demonstrated that  S. boulardii  administration could change the gut microbiota in mice and alleviate acute liver failure, indicating a potential protective and therapeutic role of  S. boulardii .

Saccharomyces boulardii Administration Changes Gut Microbiota and Attenuates D-Galactosamine-Induced Liver Injury