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A bioresorbable metallic helical stent was explored as a new device opportunity (magnesium scaffold), which can be absorbed by the body without leaving a trace and simultaneously allowing restoration of vasoreactivity with the potential for vessel remodeling. In this study, developed Mg-based helical stent was inserted and expanded in vessels with subsequent degradation in various environments including static, dynamic, and porcine  ex vivo  models. By assessing stent degradation in three different environments, we observed: (1) stress- and flow-induced degradation; (2) a high degradation rate in the dynamic reactor; (3) production of intermediate products (MgO/Mg(OH) 2  and Ca/P) during degradation; and (4) intermediate micro-gas pocket formation in the neighboring tissue  ex vivo  model. Overall, the expandable Mg-based helical stent employed as a scaffold performed well, with expansion rate (>100%) in porcine  ex vivo  model.

Expandable Mg-based Helical Stent Assessment using Static, Dynamic, and Porcine Ex Vivo Models