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Species from the genus  Talaromyces  produce useful biomass-degrading enzymes and secondary metabolites. However, these enzymes and secondary metabolites are still poorly understood and have not been explored in depth because of a lack of comprehensive genetic information. Here, we report a 36.51-megabase genome assembly of  Talaromyces pinophilus  strain 1–95, with coverage of nine scaffolds of eight chromosomes with telomeric repeats at their ends and circular mitochondrial DNA. In total, 13,472 protein-coding genes were predicted. Of these, 803 were annotated to encode enzymes that act on carbohydrates, including 39 cellulose-degrading and 24 starch-degrading enzymes. In addition, 68 secondary metabolism gene clusters were identified, mainly including T1 polyketide synthase genes and nonribosomal peptide synthase genes. Comparative genomic analyses revealed that  T. pinophilus  1–95 harbors more biomass-degrading enzymes and secondary metabolites than other related filamentous fungi. The prediction of the  T. pinophilus  1–95 secretome indicated that approximately 50% of the biomass-degrading enzymes are secreted into the extracellular environment. These results expanded our genetic knowledge of the biomass-degrading enzyme system of  T .  pinophilus  and its biosynthesis of secondary metabolites, facilitating the cultivation of  T .  pinophilus  for high production of useful products.

Genome sequencing and analysis of Talaromyces pinophilus provide insights into biotechnological applications