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The commensal fungus  Candida albicans  often causes life-threatening infections in patients who are immunocompromised with high mortality. A prominent but poorly understood risk factor for the  C. albicans  commensal‒pathogen transition is the use of broad-spectrum antibiotics. Here, we report that β-lactam antibiotics cause bacteria to release significant quantities of peptidoglycan fragments that potently induce the invasive hyphal growth of  C. albicans . We identify several active peptidoglycan subunits, including tracheal cytotoxin, a molecule produced by many Gram-negative bacteria, and fragments purified from the cell wall of Gram-positive  Staphylococcus aureus . Feeding mice with β-lactam antibiotics causes a peptidoglycan storm that transforms the gut from a niche usually restraining  C. albicans  in the commensal state to promoting invasive growth, leading to systemic dissemination. Our findings reveal a mechanism underlying a significant risk factor for  C. albicans  infection, which could inform clinicians regarding future antibiotic selection to minimize this deadly disease incidence.

A peptidoglycan storm caused by β-lactam antibiotic’s action on host microbiota drives Candida albicans infection