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IN ACUTE leukaemia, mature granulocytes are usually reduced in peripheral blood and bone marrow. In such cases it could be considered that normal haemopoietic stem cells are merely replaced by leukaemic cells in haemopoietic organs or that normal haemopoietic stem cells are suppressed by leukaemic cells through such mechanisms as cell-to-cell interaction, humoral factors produced by leukaemic cells and so on. Therefore, we wished to check the effects of leukaemic cells on non-leukaemic bone marrow cells when the two were cultured by the soft agar culture technique. Suppressive effects of leukaemic cells on non-leukaemic marrow cell colony formation were clearly observed.

Influence of leukaemic cells on the colony formation of human bone marrow cells in vitro