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Summary  Small numbers of  Salmonella dublin  were used to infect calves in an attempt to simulate natural infection on the farm.  Twenty calves were exposed to  S. dublin  by one or more of the following methods:  Sucking cows which were excreting  S. dublin  in their faeces (⋜ 10 2 –10 5  organisms/g).  Housing on  S. dublin  contaminated bedding.  Drinking  S. dublin  contaminated water (10 2 –10 4  organisms/ml). During this experiment some calves were given therapeutic doses of oxytetracycline.  After exposure the calves were examined for faecal excretion of  S. dublin  (in some instances mouth swabs and blood samples were also examined) and for clinical signs of illness. Most of the calves became infected with  S. dublin  but excretion was usually sporadic and the numbers of salmonellas excreted were small. No clinical signs of salmonellosis were observed by  S. dublin  was isolated from one calf at  post-mortem .  Another six calves, dosed orally with either 10 6  or 10 8  S. dublin , showed signs of mild illness and although three calves had diarrhoea excretion of salmonellas was intermittent.  S. dublin  was isolated from one of these calves at  post-mortem .

Salmonella dublin infection of calves: use of small doses to simulate natural infection on the farm