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The mice employed in this study were a non-inbred strain (L. A. a. Grey) developed at the Laboratory Anirnals Centre, Medical Research Council Laboratories, (:arshalton. Preliminary sighting tests showed that this laboratory strain of mice was more susceptible to warfarin poisoning than the wild species. Twelve out of twenty L.A.(J. Greys were killed after feeding on bait containing 0J005 °/O warfarin for 3 days compared with only six out of thirty wild mice fed on bait containing 0@025 °/O warfarin over the same period. One hundred (fifty male and fifty female) L. A. C. Grey mice were paired at random when they were 6 weeks old; each pa.ir was placed in a container measuring 12x5x4in. and supplied with a composite diet (diet 41b) and water acZ lib. The date of birth of litters was recorded aJnd the litters taken from their parents when they were 3 weeks old. Littermates were housed together until they were 5 weeks of age and then isolated in metal test-cages measuring 14 x 11 x 6 in. The adult pairs were allowed to breed a second time and each male was removed from its breeding female as soon as the latter was again clearly pregnant. The dates of birth of second litters were recorded and the young removed from their mothers when they were 3-4 weeks old. Littermates of the same sex were kept together until they had reached the age of 22 weeks at which time they were isolated in test cages. Parent mice were similarly ca,ged 2 weeks prior to poisoning.

The effect of sex and age on the response to warfarin in a non-inbred strain of mice