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In a previous publication (Fell & Brieger, 1947), it was shown that virulent strains of avian tubercle bacilli which killed rabbits and fowls in 3-4 weeks (Yersin type of infection) did not prevent the active growth of tissue cultures of embryonic chick lung, even when the explants were inoculated with a dense bacillary suspension. Specific lesions and toxic effects were absent, and the cultures survived for 3-6 weeks in spite of heavy intracellular infection. On the other hand, the infection was never eliminated by the tissue. Eventually the living cultures seemed to be disrupted mechanically by the proliferation of the bacilh. These results were confirmed in unpublished experiments in which tissue cultures of young rabbit spleens were infected with virulent avian bacilli. These observations agreed with those of. Smith, Willis & Lewis (1922), who maintained for a few days cultures of embryonic chick tissues infected with moderately virulent organisms of the avian type, but saw no tubercle formation or degenerative changes. Fischer (1927) cultivated tumour tissues of a tuberculous fowl and noted a complete symbiosis between the cells and the bacilli which they contained. On the other hand, Maximow (1924, 1928), Haagen (1928), and Timofejewsky & Benevolenskaja (1928) found that highly virulent mammalian strains were very injurious to tissue explants from susceptible hosts. These observations suggested that organisms which are pathogenic in the body might be expected to have a rapidly injurious effect on cultures of tissues from a susceptible animal. Our observations on fowl and rabbit tissue cultures infected with bacilli of the avian type, however, have shown that this is not a principle of general application. In view of this disparity between the results described for susceptible tissue cultures infected with avian and mammalian strains respectively, we decided to reinvestigate the behaviour of rabbit tissue cultures infected with virulent bovine tubercle bacilh'. The results of this investigation have already been briefly mentioned by one of us (Brieger, 1949), and are described in full in the present paper. The investigation was made in two parts. In Part I, described in the present

epidemiology and infection

A comparative study of the reaction <i>in vivo</i> and <i>in vitro</i> of rabbit tissues to infection with bovine tubercle bacilli: Part II. Observations on cultures of spleen and lymph glands from infected rabbits

A comparative study of the reaction in vivo and in vitro of rabbit tissues to infection with bovine tubercle bacilli: Part II. Observations on cultures of spleen and lymph glands from infected rabbits