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A study was made of the development of skin resistance and delayed hyper-sensitivity to vaccinia virus after immunization with inactivated vaccinia virus in rabbits. These vaccines are shown to increase skin resistance, and it is also shown that the development of this resistance is dependent upon the virus content of the vaccine. Skin resistance is shown to be related to the titre of circulating antibody rather than to the degree of delayed hypersensitivity. Possible reasons for conflicting reports in the literature on this subject are discussed. An unusual skin reaction was seen in some animals when challenged with live virus after immunization with inactivated vaccine. The nature of these reactions is discussed.

The development of skin resistance and hypersensitivity following inactivated vaccinia virus vaccines in rabbits