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Very little information is available on the pathogenesis of rinderpest in any domestic animal or on the routes and duration of virus excretion; such data as exist (see Curasson, 1932, 1942) are usually fragmentary and qualitative. The recent development of tissue-culture techniques, for the quantitative recovery of virulent strains of rinderpest virus from animal tissues, has made it possible to re-investigate these problems in a systematic, though economical, manner. Studies of this type have a practical significance in indicating the optimal time for collection of materials for diagnostic purposes. They also assist in reaching sound conclusions on the epizootiology of the disease and have a comparative value for those interested in infections caused by the closely-related agents of human measles and canine distemper. The first paper of this series describes the results of experiments designed to elucidate the relationships between viraemia, clinical signs and virus excretion in cattle infected with a single field isolate of moderately high virulence.

Studies on the pathogenesis of rinderpest in experimental cattle I. Correlation of clinical signs, viraemia and virus excretion by various routes