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IN this Institute a lung disease of the laboratory rat has been well known and recognized as a clinical entity since Petrie & Macalister (1911) and Macalister & Brooks (1914) described the condition among wild rats under examination for plague in Suffolk and Essex. Petrie describes the macroscopic appearance of the lesions as follows: "In the early stages, the lungs were found on incision to contain one or more small cavities, full of glairy, semipurulent material. In advanced stages, the normal lung tissue was replaced almost entirely by a system of large cavities full of thick caseous pus." It would appear that this same condition has been studied recently by Passey et al. (1936) in their paper on "Bronchiectasis and metaplasia of the laboratory rat". It has also been the object of bacteriological investigation. Ordinary microscopical and cultural methods, however, have so far yielded no definite information with regard to a possible causative agent. Consistent isolation of a particular organism has never been obtained though some interesting findings have been published. Meyer (1928) supplies a useful resume of these reported findings in rat "pneumonia" together with some notes of his own observations.

On a pleuropneumonia-like organism in lung lesions of rats, with notes on the clinical and pathological features of the underlying condition