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REPORTS on the isolation of pleuropneumonia-like organisms have been frequent during the last few years, and there can be no doubt that we are dealing here with a widely spread group of organisms. In 1935 the writer reported the occurrence in cultures of Streptobacillus moniliformis of a pleuropneumonia-like organism, LI, recoverable therefrom in a pure state and interpreted the association as one of symbiosis. Since then she has found and placed on record several new species of pleuropneumonia-like organisms occurring independently and not in apparent symbiosis with bacteria. New information, collected in both these fields during the past year, forms the subject of this communication and is discussed under the following headings: A. The relationship of Ll to S. moniliformis: symbiont or variant? B. A new strain resembling S. moniliformis isolated from abscesses in the necks of guinea-pigs. C. Other probable associations from which the symbiont has not so far been obtained in pure condition. D. Pleuropneumonia-like organisms occurring independently in lesions in rats or mice: (a) L3—bronchiectatic lesions in rats. (See p. 210.) (6) L4—-abscesses, arthritis and swollen glands in rats. (c) L5—-"rolling disease" in mice. (d) L6—from brains of mice inoculated intracerebrally with blood of splenectomized mice containing Eperythrozoon coccoides. (e) "M55"—arthritis in mice. E. Further studies on the filterable organisms isolated from sewage, soil, etc.

The pleuropneumonia-like organisms: further comparative studies and a descriptive account of recently discovered types