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Summary  The various lethal t -haplotypes are divided into several complementation groups defined by lethality of t  x / t  y heterozygotes, and only partial complementation is usually observed in heterozygotes between t complementation groups. Several effects of the t region have been found to be preferentially or exclusively detectable in males. This paper describes results showing that the viability of t  6 / t  w5 heterozygotes is influenced by the sex of the embryo; female viability is only slightly reduced (viability ratio approximately 0·80), while male viability is far below normal (0·25).

genetical research

Lethality of heterozygotes betweent-haplotype complementation groups of mouse: sex-related effect on lethality oft6/tw5heterozygotes