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To assess whether endothelin-1 (ET-1) induces the in vivo expression of inflammatory-related proteins, namely cyclooxygenase-2 (COX-2) and tissue factor, in the myocardium and circulating leukocytes of guinea-pigs. The involvement of platelets was also analyzed.

Endothelin-1 induced proinflammatory markers in the myocardium and leukocytes of guinea-pigs Role of glycoprotein IIB/IIIA receptors