z-logo
open-access-imgOpen Access
Synchronous primary mammary osteosarcoma and invasive breast cancer. A case report – Pathohistological and immunohistochemical analysis
Author(s) -
Lena Marinova,
T. Hadjieva,
Emil Kanchev,
Svetla Vicheva
Publication year - 2015
Publication title -
reports of practical oncology and radiotherapy
Language(s) - English
Resource type - Journals
eISSN - 2083-4640
pISSN - 1507-1367
DOI - 10.1016/j.rpor.2014.04.003
Subject(s) - medicine , breast cancer , immunohistochemistry , quadrant (abdomen) , radiation therapy , sarcoma , chemotherapy , pathology , modified radical mastectomy , osteosarcoma , cancer , mastectomy , oncology , radiology
Primary osteogenic sarcoma of the breast is a rare neoplasm, diagnosed mainly by pathohistological and immunohistochemical analysis. We hereby present a case of primary osteogenic sarcoma in the right breast of a 62-year-old woman with synchronous appearance of an invasive ductal carcinoma. Clinical findings are manifested with two separate painless formations 2.5 cm/2 cm and 1.5 cm/1 cm in size, located on the border of the upper and lower lateral quadrant of the right breast. No axillary lymphadenopathy was diagnosed. The pathohistological and immunohistochemistry findings of both tumors revealed a synchronous manifestation of two distinct neoplasms - epithelial and non-epithelial. Multimodality treatment consisted of Patey's radical mastectomy; 3 cycles of adjuvant chemotherapy; postoperative 50 Gy radiotherapy to the chest wall followed by additional 3 cycles of chemotherapy and anti-estrogen hormonotherapy. Due to the rarity of osteogenic mammary sarcoma, even more so in a combination with epithelial breast tumors, its clinical features are unclear and optimal treatment remains controversial. Considering the poor prognosis of the combination of both malignomas, we discuss a number of diagnostic and therapeutic issues.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here