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BackgroundSpinal cord injury (SCI) is associated with bone mass loss that can be complicated by fractures, which result in further disabilities for patients. After a SCI, the body starts losing large amounts of calcium and other minerals in the urine (demineralisation). This study aimed to assess the changes in bone mineral density (BMD) during the 1st year of acute SCI in patients with neurological deficit.MethodsA total of 95 patients with acute SCI and neurological deficit were evaluated in this prospective study. Haematological investigations such as evaluation of serum calcium, serum phosphate, serum creatinine, and serum alkaline phosphatase (ALP) were carried out. Urinary investigations such as 24-hour urinary creatinine level and excretion of calcium and phosphate in the urine were measured. BMD was measured using dual-energy X-ray absorptiometry scan with Hologic QDR 2000 scanner (Explorer). All of the aforementioned parameters were measured again at 3, 6, and 12 months.ResultsSerum ALP at 1-year follow up was significantly raised (p<0.05). The BMD at 1-year follow up had statistically significant lower values than the initial BMD at the hip (p<0.05), proximal tibia (p < 0.00l), and distal tibial epiphysis (p < 0.001). The BMD in motor-complete SCI patients [American Spinal Injury Association (ASIA) grades A and B] had significant lower values than motor-incomplete SCI patients (ASIA C and D) at the hip (p < 0.05) and proximal tibial epiphysis (p < 0.05).ConclusionThere was a marked decrease in BMD in metaphyseal sites than below the neurological deficit level with maximum decrease at the proximal tibia during the 1st year of SCI. Although the markers of osteoblastic activity did not show much change, the decrease in BMD was influenced by the neurological recovery after SCI

Bone Mineral Density and Biochemical Markers of Bone Turnover during the First Year of Injury in Patients with Spinal Cord Injury