Open AccessGSK1702934A and M085 directly activate TRPC6 via a mechanism of stimulating the extracellular cavity formed by the pore helix and transmembrane helix S6
Author(s) -
Peilin Yang,
Xinghua Li,
Jin Wang,
Xuefei Ma,
Bo-Ying Zhou,
Yuan-Feng Jiao,
Wenhui Wang,
Peng Cao,
Michael X. Zhu,
Pei-Wang Li,
Zhihong Xiao,
Changzhu Li,
Chang-Run Guo,
Yuntao Lei,
Ye Yu
Publication year - 2021
Publication title -
journal of biological chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.361
H-Index - 513
eISSN - 1067-8816
pISSN - 0021-9258
DOI - 10.1016/j.jbc.2021.101125
Subject(s) - trpc , extracellular , trpc6 , transient receptor potential channel , transmembrane domain , biophysics , chemistry , helix (gastropod) , gating , transmembrane protein , biochemistry , microbiology and biotechnology , biology , amino acid , receptor , ecology , snail
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