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Background: Polymorphisms of different gene have been reported to be associated with cancer including breast cancer. Hospitalization rate for breast cancer has increased over the years in Iran.Aim: The aim of this study was to examine whether polymorphisms in the CYP3A4 and CYP3A5 genes affect the risk of developing breast cancer.Subjects and methods: The genotype distribution and allele frequencies of four CYP3A4*1A, CYP3A4*1B, CYP3A5*1 and CYP3A5*3 single-nucleotide polymorphisms were determined in 250 subjects from the general population in Ahvaz city (southwest of Iran) including 200 healthy subjects and 50 individuals affected with breast cancer.Results and conclusion: The genotype frequency of CYP3A4*1A/*1A (A/A) in both case and control groups was 100%; however, there was no subject with either CYP3A4 * 1A/ * 1B (A/G) or CYP3A4*1B/*1B (G/G) genotype. For CYP3A5 gene, CYP3A5*3/*3mutant homozygote genotype frequency was found to be 99% (n = 198) and 98% (n = 49) in control and patient groups respectively. CYP3A5*1/*1 wild-type genotype was calculated to be 1% (n = 2) in the control group and 2% (n = 1) in the case group. No. CYP3A5*1/*3 heterozygote genotype was detected in the both groups. The results showed that there was no association between breast cancer, CYP3A5 (P-value = 0.561) and CYP3A4 allele distribution

Association of CYP3A4 and CYP3A5 polymorphisms with Iranian breast cancer patients