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BackgroundThe Renin-Angiotensin System (RAS) is an important regulator for blood pressure and kidney disease. The level of vaso active peptide Angiotensin-II is mainly determined by the RAS enzyme angiotensin converting enzyme-1 (ACE-1).AimTo investigate the association of ACE I/D polymorphism and Chronic Kidney Disease (CKD) in south India.MethodsIn the present study, we have collected CKD patients (n=147) and control subjects (n=211) from Tamilnadu. Genotyping was carried out by polymerase chain reaction (PCR) on the basis of allele specific primers.ResultsThe DD genotype is associated with the female population (OR-CI=2.40 (1.05–5.51), p=0.04) as compared to the male population (OR-CI=0.75 (0.37–1.51), p=0.42). Further, we found the over representation of “I” – allele (homozygous II and heterozygous ID) in unaffected males [OR (CI) – 0.58 (0.32–1.04), p=0.07] which suggests its protective role in male population.ConclusionThe DD genotype of ACE is associated with CKD in south India

ACE DD genotype associated with the female Chronic Kidney Disease patients of Tamilnadu population