Inhibition of T cell homing by down-regulation of CD62L and the induction of a Th-2 response as a method to prevent acute allograft rejection in mice☆ | Zendy

Christian Stremmel | Zendy; Wulf Sienel | Zendy; Stephan Eggeling | Zendy; Bernward Passlick | Zendy; Anthony Slavin | Zendy

Open Access

Inhibition of T cell homing by down-regulation of CD62L and the induction of a Th-2 response as a method to prevent acute allograft rejection in mice☆

Author(s) -

Christian Stremmel,

Wulf Sienel,

Stephan Eggeling,

Bernward Passlick,

Anthony Slavin

Publication year - 2006

Publication title -

european journal of cardio-thoracic surgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.303

H-Index - 133

eISSN - 1873-734X

pISSN - 1010-7940

DOI - 10.1016/j.ejcts.2006.04.014

Subject(s) - homing (biology) , medicine , immunology , biology , ecology

For a successful immune response, migration of lymphocytes to lymphoid organs and other tissues is a key step, as the initial recognition of foreign antigens and activation of lymphocytes takes place in these organs. CD62L is a homing receptor that mediates entry of naïve T cells to peripheral lymph nodes. Maybe the preventing of T cell homing will change the immune response against allogeneic tissue and suppress rejection.

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