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A recent study reported that a nonsynonymous SNP rs2241880 (c.898A&gt;G, p.Thr300Ala) within ATG16L1 confers susceptibility to Crohn's disease (CD). We analyzed ATG16L1 c.898A&gt;G in three independent European inflammatory bowel disease (IBD) cohorts from Germany, Hungary and the Netherlands.

A study in three European IBD cohorts confirms that the ATG16L1 c.898A>G (p.Thr300Ala) variant is a susceptibility factor for Crohn’s disease