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Extracellular retention of PDGF-B has been proposed to play an important role in PDGF-B signalling. We used the PDGF-B retention motif knockout mouse (RetKO) to study the effects of retention motif deletion on development of micro- and macrovascular structure and function.

Platelet-derived growth factor B retention is essential for development of normal structure and function of conduit vessels and capillaries☆