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We have recently shown that pretreatment of A10 vascular smooth muscle cells (VSMC) with angiotensin II (Ang II) for 24 h enhanced the expression of Gialpha-proteins, however, Gialpha-mediated adenylyl cyclase signaling was attenuated. Since regulators of G-protein signaling (RGS) have been shown to negatively regulate the Galpha-protein, we investigated the role of RGS2, in Ang II-induced attenuation of Gialpha-mediated signaling in A10 vascular smooth muscle cells (VSMC).

Angiotensin II-evoked enhanced expression of RGS2 attenuates Gi-mediated adenylyl cyclase signaling in A10 cells