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Post-translational modifications (PTMs), specifically serine phosphorylation, are essential for determination and tuning up an activity of many proteins, including those that are involved in the control of gene transcription. Transcription factors PPARγ2 and RUNX2 are essential for mesenchymal stem cell (MSC) commitment to either adipocyte or osteoblast lineage. This review is summarizing current knowledge how serine phosphorylation PTMs regulate activities of both transcription factors and MSCs lineage commitment.

Reciprocal Regulation of PPARγ and RUNX2 Activities in Marrow Mesenchymal Stem Cells: Fine Balance between p38 MAPK and Protein Phosphatase 5